Motif ID: HOX{A5,B5}.p2

Z-value: 1.554


Transcription factors associated with HOX{A5,B5}.p2:

Gene SymbolEntrez IDGene Name
HOXA5 3202 homeobox A5
HOXB5 3215 homeobox B5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v1_chr17_-_46671043_466711580.383.1e-02Click!
HOXA5hg19_v1_chr7_-_27183225_271832860.183.2e-01Click!


Activity profile for motif HOX{A5,B5}.p2.

activity profile for motif HOX{A5,B5}.p2


Sorted Z-values histogram for motif HOX{A5,B5}.p2

Sorted Z-values for motif HOX{A5,B5}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A5,B5}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_161193190 7.981 APOA2
apolipoprotein A-II
chr1_-_161193375 7.677 NM_001643
APOA2
apolipoprotein A-II
chr19_+_41515495 7.323 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr12_+_50497790 7.198 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr13_-_46679143 6.867 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr3_-_164914448 6.440 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr11_-_2018885 6.222 H19
RPS12
H19, imprinted maternally expressed transcript (non-protein coding)
ribosomal protein S12
chr7_-_99381703 6.220 NM_001202855
NM_017460
CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr2_-_88427535 6.138 NM_001443
FABP1
fatty acid binding protein 1, liver
chr11_-_2019007 5.822 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr10_+_104590430 5.395


chr7_+_5322553 5.068 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr12_-_9268513 5.067 A2M
alpha-2-macroglobulin
chr12_+_56075329 4.989 NM_152637
METTL7B
methyltransferase like 7B
chr14_+_21498344 4.921 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr5_-_35048239 4.607 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr12_-_91572328 4.536 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr20_+_42984088 4.535 HNF4A
hepatocyte nuclear factor 4, alpha
chr2_+_234601511 4.490 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr16_-_71610948 4.479 NM_000353
TAT
tyrosine aminotransferase
chr1_-_163113129 4.468 RGS5
regulator of G-protein signaling 5
chr3_-_42917632 4.367 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chrX_+_151084708 4.071 NM_002362
MAGEA4
melanoma antigen family A, 4
chr1_+_145413190 4.060 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr6_-_46620229 3.988 NM_016593
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr5_+_133842276 3.975


chr3_-_195538699 3.974 NM_004532
NM_018406
NM_138297
MUC4


mucin 4, cell surface associated


chr1_+_203444882 3.970 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr11_-_2018446 3.969 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr12_+_56075418 3.741 METTL7B
methyltransferase like 7B
chr11_+_74862031 3.704 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chr14_-_23904849 3.614 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr19_-_42348507 3.461 NM_173506
LYPD4
LY6/PLAUR domain containing 4
chr12_-_56101465 3.423 ITGA7
integrin, alpha 7
chr10_+_115310589 3.392 NM_001177660
HABP2
hyaluronan binding protein 2
chr11_-_2018334 3.388 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr1_+_114522029 3.340 NM_020190
OLFML3
olfactomedin-like 3
chr2_+_17721806 3.319 NM_003385
VSNL1
visinin-like 1
chrX_+_151086708 3.283 NM_001011550
MAGEA4
melanoma antigen family A, 4
chr15_-_75017710 3.281 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr11_-_35440514 3.259 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr6_+_31868775 3.204 NM_001178063
C2
complement component 2
chrX_+_151085396 3.138 NM_001011549
MAGEA4
melanoma antigen family A, 4
chr19_-_48495339 3.058 NM_001128326
BSPH1
binder of sperm protein homolog 1
chr12_+_7167979 3.036 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr20_+_44350987 3.029 NM_178455
SPINT4
serine peptidase inhibitor, Kunitz type 4
chr4_-_114900802 3.028 NM_024590
ARSJ
arylsulfatase family, member J
chr14_+_21236585 2.929 NM_022360
EDDM3B
epididymal protein 3B
chr9_+_27109138 2.925 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr17_-_7166505 2.924 NM_001185022
CLDN7
claudin 7
chr10_+_122216465 2.918 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr1_+_203444955 2.895 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr13_-_110802708 2.876 COL4A1
collagen, type IV, alpha 1
chr2_+_201473942 2.871 AOX1
aldehyde oxidase 1
chr17_-_46894380 2.870 NM_001130918
TTLL6
tubulin tyrosine ligase-like family, member 6
chr16_+_71560022 2.866 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr9_-_112970412 2.840 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr9_+_35673852 2.838 NM_001216
CA9
carbonic anhydrase IX
chr3_-_42917191 2.829 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr4_-_110723334 2.693 NM_000204
CFI
complement factor I
chr3_+_11034436 2.657 SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr2_+_17721983 2.640 VSNL1
visinin-like 1
chr18_-_48346297 2.546 NM_001127175
NM_001127176
NM_031939
MRO


maestro


chr11_-_125648704 2.538 NM_212555
PATE2
prostate and testis expressed 2
chr12_-_125348346 2.532 SCARB1
scavenger receptor class B, member 1
chrX_+_100333835 2.456 NM_021637
TMEM35
transmembrane protein 35
chr2_-_217540722 2.451 IGFBP5
insulin-like growth factor binding protein 5
chr19_-_50266514 2.398 NM_021733
TSKS
testis-specific serine kinase substrate
chr17_+_6679551 2.395 NM_153230
FBXO39
F-box protein 39
chr11_-_2018568 2.375 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr19_-_291335 2.362 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr3_+_11034419 2.332 NM_003042
SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr11_-_125550674 2.320 NM_001612
NM_020069
NM_020107
NM_020108
ACRV1



acrosomal vesicle protein 1



chr20_-_6034617 2.288 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr16_+_31539202 2.258 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr11_-_57283145 2.232 NM_003627
SLC43A1
solute carrier family 43, member 1
chrX_-_6453158 2.217 NM_016379
VCX2
VCX3A
variable charge, X-linked 2
variable charge, X-linked 3A
chr2_-_56151273 2.190 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr7_-_140302311 2.153 NM_015689
DENND2A
DENN/MADD domain containing 2A
chr4_+_123300594 2.148 NM_001159285
NM_001159295
ADAD1

adenosine deaminase domain containing 1 (testis-specific)

chr11_+_125703210 2.114 NM_001144874
PATE4
prostate and testis expressed 4
chr17_-_26697293 2.088 VTN
vitronectin
chr1_-_41487386 2.073 NM_001168247
NM_144990
SLFNL1

schlafen-like 1

chr7_+_79082910 2.046 MAGI2-AS3
MAGI2 antisense RNA 3 (non-protein coding)
chr1_+_162351519 2.046 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr12_+_26205490 2.015 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr20_-_56100138 2.006 NM_080618
CTCFL
CCCTC-binding factor (zinc finger protein)-like
chr10_-_118032975 2.000 NM_005264
GFRA1
GDNF family receptor alpha 1
chr7_+_45927958 1.983 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr1_+_4714668 1.981 AJAP1
adherens junctions associated protein 1
chr11_-_57004674 1.977 NM_005161
APLNR
apelin receptor
chrX_+_8432870 1.940 NM_001001888
VCX3B
VCX3A
variable charge, X-linked 3B
variable charge, X-linked 3A
chr13_+_52436116 1.917 NM_031290
CCDC70
coiled-coil domain containing 70
chr19_-_14064192 1.879 NM_001146254
NM_001146255
PODNL1

podocan-like 1

chr1_-_153958688 1.869 NM_002870
RAB13
RAB13, member RAS oncogene family
chrX_-_139047676 1.860 NM_001013403
CXorf66
chromosome X open reading frame 66
chr22_-_22901421 1.857 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr12_-_6484557 1.853 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr12_-_125348422 1.834 NM_001082959
NM_005505
SCARB1

scavenger receptor class B, member 1

chr11_-_57089670 1.806 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chrX_+_51546154 1.802 NM_001005332
MAGED1
melanoma antigen family D, 1
chr15_+_82647307 1.784 UBE2Q2P2
ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 2
chr4_-_100140330 1.751 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr7_-_98030165 1.750 BAIAP2L1
BAI1-associated protein 2-like 1
chr2_-_74726665 1.747 LBX2
ladybird homeobox 2
chr8_+_7705401 1.744 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr10_+_96522457 1.737 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr16_+_86544104 1.732 NM_001451
FOXF1
forkhead box F1
chr20_-_22564893 1.718 FOXA2
forkhead box A2
chr19_-_50143350 1.713 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr1_-_23810627 1.669 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chrY_+_26979966 1.669 NM_020364
NM_001005785
NM_001005786
NM_001005375
NM_020420
DAZ3
DAZ2

DAZ4

deleted in azoospermia 3
deleted in azoospermia 2

deleted in azoospermia 4

chrY_-_26959423 1.667 NM_020364
NM_020420
DAZ3
DAZ4
deleted in azoospermia 3
deleted in azoospermia 4
chr12_-_125348266 1.666 SCARB1
scavenger receptor class B, member 1
chr16_-_49860917 1.665 NM_015069
ZNF423
zinc finger protein 423
chr5_-_38595506 1.662 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr5_-_35938736 1.650 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr13_-_114538953 1.647 NM_001143945
GAS6
growth arrest-specific 6
chr17_-_26697224 1.632 VTN
vitronectin
chr3_-_170744458 1.627 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr11_-_18258315 1.624 SAA4
serum amyloid A4, constitutive
chr2_-_216300444 1.611 FN1
fibronectin 1
chr7_+_100187195 1.611 NM_001163499
NM_012172
FBXO24

F-box protein 24

chrX_-_153847390 1.605 NM_001327
NM_139250
CTAG1B
CTAG1A
cancer/testis antigen 1B
cancer/testis antigen 1A
chrX_-_8769377 1.595 NM_001171186
NM_174951
FAM9A

family with sequence similarity 9, member A

chr8_-_93107442 1.591 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr8_-_93107881 1.584 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr2_+_44001177 1.580 NM_001193464
NM_015522
NM_016008
DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr20_-_50418946 1.576 NM_020436
SALL4
sal-like 4 (Drosophila)
chrX_+_105412297 1.571 NM_001171020
NM_152423
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr17_-_73505914 1.571 NM_001142643
CASKIN2
CASK interacting protein 2
chr6_+_121756744 1.569 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr19_-_55866063 1.566 NM_144613
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chrX_-_38079980 1.530 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chrX_-_104465349 1.528 NM_031274
TEX13A
testis expressed 13A
chr17_-_26697310 1.526 VTN
vitronectin
chr1_+_16085245 1.517 NM_017556
FBLIM1
filamin binding LIM protein 1
chr12_-_9268475 1.493 A2M
alpha-2-macroglobulin
chr17_+_38599651 1.487 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr11_-_2018703 1.485 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr19_+_48216600 1.483 NM_014601
EHD2
EH-domain containing 2
chr16_+_2069520 1.478 NM_001099456
NPW
neuropeptide W
chr2_-_167350655 1.477 SCN7A
sodium channel, voltage-gated, type VII, alpha
chr19_-_16008870 1.477 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr13_-_39564857 1.456 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr1_-_153599969 1.453 NM_001024211
S100A13
S100 calcium binding protein A13
chr6_+_31082526 1.452 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr10_-_94003002 1.445 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr19_+_51152634 1.430 NM_001195076
C19orf81
chromosome 19 open reading frame 81
chr6_-_33714681 1.427 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr14_-_21058880 1.427 NM_001024822
RNASE12
ribonuclease, RNase A family, 12 (non-active)
chr6_-_41006927 1.425 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chrY_+_25365580 1.418 NM_020364
NM_001005785
NM_001005786
NM_020363
NM_020420
DAZ3
DAZ2


DAZ4
deleted in azoospermia 3
deleted in azoospermia 2


deleted in azoospermia 4
chr9_-_34710062 1.416 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr20_-_42816217 1.405 NM_020433
NM_175913
JPH2

junctophilin 2

chr13_+_58205943 1.402 PCDH17
protocadherin 17
chr1_+_169337193 1.398 NM_003666
BLZF1
basic leucine zipper nuclear factor 1
chrX_-_128657381 1.384 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr8_-_30706532 1.383 NM_031271
TEX15
testis expressed 15
chr3_-_109056333 1.372 DPPA4
developmental pluripotency associated 4
chr17_+_7623038 1.371 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chrX_-_8139307 1.370 NM_016378
VCX2
variable charge, X-linked 2
chr6_+_161123224 1.369 NM_000301
NM_001168338
PLG

plasminogen

chr4_+_22694547 1.368 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chrX_+_37892786 1.367 NM_001163334
SYTL5
synaptotagmin-like 5
chr9_+_116172934 1.365 NM_152786
C9orf43
chromosome 9 open reading frame 43
chr19_-_49243836 1.353 NM_017805
RASIP1
Ras interacting protein 1
chrX_-_111326003 1.347 NM_012471
TRPC5
transient receptor potential cation channel, subfamily C, member 5
chr1_+_10490774 1.337 NM_001243768
APITD1-CORT
APITD1-CORT readthrough
chr1_-_153600714 1.334 NM_005979
S100A13
S100 calcium binding protein A13
chr13_+_29598746 1.331 NM_001033602
MTUS2
microtubule associated tumor suppressor candidate 2
chr12_-_6484904 1.322 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr12_+_54519836 1.321 LOC400043
uncharacterized LOC400043
chr19_-_291168 1.315 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr1_+_160085519 1.312 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chrX_+_114524291 1.307 NM_016383
LUZP4
leucine zipper protein 4
chr13_+_58205788 1.303 NM_001040429
PCDH17
protocadherin 17
chr13_-_114018201 1.301 GRTP1
growth hormone regulated TBC protein 1
chr1_-_1310522 1.296 AURKAIP1
aurora kinase A interacting protein 1
chrX_-_119249774 1.285 NM_139282
RHOXF1
Rhox homeobox family, member 1
chr6_-_31981049 1.276 NM_032470
TNXB
tenascin XB
chr1_+_82266081 1.272 NM_012302
LPHN2
latrophilin 2
chr16_+_15489619 1.261 MPV17L
MPV17 mitochondrial membrane protein-like
chr3_-_58522873 1.257 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr17_+_4675175 1.257 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr11_+_71238312 1.234 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr1_+_157963310 1.234 KIRREL
kin of IRRE like (Drosophila)
chr2_+_102770401 1.234 NM_000877
IL1R1
interleukin 1 receptor, type I
chr11_+_75428864 1.225 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr7_+_99425635 1.217 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr20_+_42984338 1.216 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr6_-_46922533 1.208 NM_015234
GPR116
G protein-coupled receptor 116
chr8_-_22785228 1.208 NM_144962
PEBP4
phosphatidylethanolamine-binding protein 4
chr20_-_22565050 1.207 NM_021784
FOXA2
forkhead box A2
chr15_+_82944821 1.207 AGSK1
golgin subfamily A member 2-like
chr22_+_25591072 1.202 KIAA1671
KIAA1671
chr9_-_33395265 1.192 AQP7
aquaporin 7
chr8_-_17752847 1.189 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr19_-_51845377 1.183 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr6_-_10419786 1.178 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
8.69 2.72e-06 GO:0006805 xenobiotic metabolic process
8.69 2.72e-06 GO:0071466 cellular response to xenobiotic stimulus
8.63 2.98e-06 GO:0009410 response to xenobiotic stimulus
2.63 1.21e-02 GO:0009611 response to wounding

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.33 8.96e-07 GO:0005576 extracellular region
2.76 5.98e-05 GO:0044421 extracellular region part
2.99 1.51e-04 GO:0005615 extracellular space
4.18 1.09e-02 GO:0005792 microsome
4.05 1.48e-02 GO:0042598 vesicular fraction
9.46 2.81e-02 GO:0031093 platelet alpha granule lumen
9.26 3.11e-02 GO:0034774 secretory granule lumen
8.89 3.78e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
8.55 4.55e-02 GO:0031983 vesicle lumen

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
6.28 1.02e-04 GO:0009055 electron carrier activity
35.56 6.40e-04 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups
8.89 6.57e-04 GO:0004497 monooxygenase activity
7.48 6.76e-04 GO:0019838 growth factor binding
20.21 7.95e-04 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
6.51 2.13e-03 GO:0020037 heme binding
11.86 2.18e-03 GO:0019825 oxygen binding
6.11 3.54e-03 GO:0046906 tetrapyrrole binding
4.73 4.69e-03 GO:0005506 iron ion binding
22.23 5.26e-03 GO:0008395 steroid hydroxylase activity
29.63 2.33e-02 GO:0004022 alcohol dehydrogenase (NAD) activity
88.88 2.63e-02 GO:0004854 xanthine dehydrogenase activity
88.88 2.63e-02 GO:0016726 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
5.20 3.29e-02 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
13.68 3.96e-02 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen